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NEWS BRIEF · Research journal

A small-molecule TREM2 agonist for Alzheimer’s disease

Source: Nature Medicine · Source publication date:

From the report

Nature Medicine, Published online: 29 October 2026; doi:10.1038/d41591-026-00055-xPreclinical analysis and a phase 1 trial support VG-3927 as a promising drug candidate for Alzheimer’s disease, demonstrating successful penetration of the central nervous system, target engagement and tolerability.

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