A tolerogenic function for gut TFH cells

From the report

Nature Immunology, Published online: 21 October 2026; doi:10.1038/s41590-026-02693-2Regulatory T (Treg) cells maintain immunological tolerance, but the cellular niches sustaining them across tissues are poorly defined. Work now identifies T follicular helper cells as a source of IL-2 that supports Treg cells in gut-associated lymphoid tissue and promotes intestinal immune homeostasis.