Autophagy limits steady-state IL-1α expression to restrain innate immunity

From the report

Nature Immunology, Published online: 30 October 2026; doi:10.1038/s41590-026-02701-5Autophagy controls pulmonary innate immunity at the steady-state by restraining IL-1α expression by alveolar macrophages. Disrupting this regulatory pathway primes lung innate immunity and enhances resistance to distinct respiratory infections, identifying an unexpected role for autophagy in determining host immune readiness.