A multi-institutional investigation of psilocybin’s effects on mouse behavior

From the report

Nature Neuroscience, Published online: 02 November 2026; doi:10.1038/s41593-026-02500-zIn a study across five independent labs, 2 mg kg−1 psilocybin in mice acutely increased avoidance-related behaviors in a robust, reproducible manner and acutely reduced fear expression, but previously reported persistent effects were modest or inconsistent.