Respiration-deficient cells require pyruvate carboxylase to suppress asparagine auxotrophy

From the report

Nature Metabolism, Published online: 27 October 2026; doi:10.1038/s42255-026-01651-4This study shows that high mitochondrial heteroplasmy drives a pyruvate carboxylase-dependent metabolic vulnerability, rendering respiration-deficient cells auxotrophic for asparagine.