Targeting GALE harnesses γδ T cells for cancer immunotherapy

From the report

Nature Cancer, Published online: 30 October 2026; doi:10.1038/s43018-026-01203-5Cancer cells can evade the immune system through mechanisms such as downregulation of MHC I molecules and expression of inhibitory ligands. Research now shows that targeting the metabolic enzyme GALE in tumor cells boosts the killing of these cells by γδ T cells through altering the glycosylation of…