BAZ2A-induced epigenetic states in cancer cells fuel palmitate accumulation in the tumor microenvironment driving CAR-T cell exhaustion

From the report

Nature Cancer, Published online: 30 October 2026; doi:10.1038/s43018-026-01267-3Wang et al. reveal that epigenetic remodeling driven by BAZ2A in renal cancer cells induces the production of palmitate that is taken up by tumor-infiltrating cells, resulting in impaired metabolic fitness of CAR-T cells via PGC-1α palmitoylation.