Suppressing neural stem cell PLA2G7 restores inhibitory circuit function and improves cognition in aging mice

From the report

Nature Aging, Published online: 14 October 2026; doi:10.1038/s43587-026-01202-2Wu, Wu and colleagues identify PLA2G7, a secreted lipid-metabolizing enzyme, as a negative regulator of inhibitory synapses in the dentate gyrus. Suppression of PLA2G7 in neural stem cells enhances synaptic transmission and cognitive performance in aged mice.