Naive T cell decline limits cancer immunity in middle-aged male mice

From the report

Nature Aging, Published online: 09 October 2026; doi:10.1038/s43587-026-01239-3Using mice and supporting human data, we show that accelerated loss of naive CD8+ T cells in male mice leads to lymph node contraction and limited cancer antigen recognition. Restoring thymic output replenished naive CD8+ T cells and improved responses to immunotherapy in middle-aged male mice.