Deep and quantitative proteomic profiling of low-volume mouse serum in a cross-sectional analysis of aging

From the report

Nature Aging, Published online: 02 November 2026; doi:10.1038/s43587-026-01242-8To address the technically challenging task of profiling the age-associated blood proteome in sample-limited mouse studies, the authors present a quantitative nanoparticle-based enrichment workflow coupled with data-independent acquisition mass spectrometry to identify key age-associated circulating proteins with relevance to human health.