Statins promote bone anabolism in estrogen deficiency by inducing osteogenic differentiation of skeletal stem/progenitor cells

From the report

Nature Aging, Published online: 27 October 2026; doi:10.1038/s43587-026-01257-1Yang et al. demonstrate that statins can compensate for reduced estrogen signaling in skeletal stem and progenitor cells, promoting bone anabolism during estrogen deficiency and suggesting therapeutic benefits beyond cholesterol management.