Hematopoietic loss of KDM6A impairs cardiac recovery in heart failure via epigenetic reprogramming of myeloid cells

From the report

Nature Cardiovascular Research, Published online: 03 November 2026; doi:10.1038/s44161-026-00887-3Solomonidis et al. reveal that hematopoietic KDM6A-driven clonal hematopoiesis worsens post-MI cardiac recovery by promoting inflammatory myeloid reprogramming. IL-1β blockade reverses these adverse effects, highlighting a potential therapeutic strategy.