Integrated single-cell transcriptomics reveals two-phase model of right ventricular failure

From the report

Nature Cardiovascular Research, Published online: 23 October 2026; doi:10.1038/s44161-026-00896-2RNA-sequencing analyses of right ventricular tissue from pediatric and adult patients, together with a mouse model of isolated pulmonary pressure overload, identify a conserved cross-species mechanistic framework that underlies progression from preserved right ventricular function to failure, characterized by two distinct phases of transcriptional changes.